John Malkovich, Frances McDormand, Tilda Swinton, George Clooney and Brad Pitt star in this Coen brothers crime comedy concerning the whereabouts of a sensitive disc containing the incriminating memoirs of alcoholic CIA agent Osbourne Cox (Malkovich). Cox's wife, Katie (Swinton), who is having an affair with married federal marshall, Harry Pfarrer (Clooney), is making plans to leave her husband, and is advised by her divorce lawyer to copy his personal files onto a disc. The disc finds its way via a circuitous route to the Hardbodies fitness gym, where two unscrupulous employees, Linda (McDormand) and Chad (Pitt) decide to exploit their find for all they can get. Events soon spiral out of everyone's control in a cascading series of surreal and darkly comic encounters and misunderstandings.