Fast-paced action thriller based on the computer game of the same name. A professional assassin known only as Agent 47 (Timothy Olyphant), hired by a group known only as 'The Agency', is ensnared in a political conspiracy which finds him on the run from both Interpol and the Russian FSB (The successors to the KGB). The hunter becomes the hunted as he is chased across Eastern Europe while, at the same time, he tries to find out who set him up and why they're trying to take him out. Unexpectedly, the greatest threat to 47's survival may be the first stirrings of his conscience and the alien emotions awakened in him by Nika (Olga Kurylenko), a beautiful woman who gets herself wrapped up in the conspiracy and, consequently, 47's life.