In Arizona 1882 nothing comes easy in the bitterly unforgiving Old West except dying. Albert (Seth MacFarlane) is a soft man in hard times who really doesn't fit in. Adding to Albert's distress and feelings of inadequacy, his girlfriend (Amanda Seyfried) leaves him for the towns moustache groomer (Neil Patrick Harris). When a mysterious and beautiful woman (Charlize Theron) rides into town she helps him find his courage. However, when her husband (Liam Neeson), a notorious outlaw, arrives seeking revenge, the farmer must put his new found courage to the test.