Computer-animated children's comedy about an arch-criminal who has a change of heart. Trying to outdo his main rival Vector (voice of Jason Segel), serial villain Gru (Steve Carell) hatches a plan to steal the moon, aided by his army of genetically altered corn pops. About to set his dastardly plan in motion, and bristling with his arsenal of freeze-rays and sci-fi gadgetry, all goes according to plan until the arrival at his door of three little orphan girls, Margo (Miranda Cosgrove), Agnes (Elsie Fisher) and Edith (Dana Gaier), in search of a father figure.