This book is an anthology of philosophical essays. Its principle is simple: the moments of our life are original. What we perceive and think does not arise from an elusive and illusive entity called God, Soul or External World. This setting, in line with philosophical and scientific trends, is the starting point for reaching a coherent and innovative solution to the problems of knowledge. In the foreground we encounter the relationship between the mind and the brain, where the terms are composed according to the analogy with music and the musical score, and then the basis of time and the sense of the Big Bang. These are the frame and sketch of the book.