The Routledge International Handbook of Mental Health Disorders in the Caribbean and African Regions addresses mental health in these locations as a critical public health priority. This comprehensive handbook emphasizes the collective societal responsibility to confront mental health challenges, advocating for interprofessional collaboration, grassroots initiatives, and equitable access to mental health services. It serves as a vital resource for updating outdated policies, enhancing mental healthcare delivery, and fostering community-centered solutions. Structured into six thematic parts, the contributors cover foundations of mental health, understanding mental health disorders, biological and epidemiological dimensions of mental ill-health and disorders, mental disorders and related health conditions, professional roles in mental health care, and societal and community roles in mental health care. This handbook spans fundamental concepts, etiology, epidemiology, advocacy, promotion, literacy, treatment, and service provision. Each chapter integrates clearly defined learning objectives, contextual principles, actionable methodologies, and reflective questions to create an engaging, practical, and impactful learning experience. Tailored for students, practitioners, policymakers, and advocates, this handbook offers evidence-based insights and strategic interventions aimed at building resilient communities in the Caribbean and African Regions.